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Type of Hyperbilirubinemia location and Cause Unconjugated hyperbilirubinemia Increased bilirubin production (eg, hemolytic anemias, hemolytic reactions, hematoma, pulmonary infarction) (predominantly indirect Impaired bilirubin uptake and storage (eg, posthepatitis hyperbilirubinemia, Gilbert syndrome, Crigler bilirubin) Najjar syndrome, drug reactions) Conjugated hyperbilirubinemia Hereditary Cholestatic Syndromes (see additionally Table sixteen-2) (predominantly direct Faulty excretion of bilirubin conjugates (eg, Dubin-Johnson syndrome, Rotor syndrome) or mutation in bilirubin) genes coding for bile salt transport proteins (eg, progressive familial intrahepatic cholestasis syndromes, benign recurrent intrahepatic cholestasis, and a few circumstances of intrahepatic cholestasis of being pregnant) Hepatocellular Dysfunction Biliary epithelial and hepatocyte harm (eg, hepatitis, hepatic cirrhosis) Intrahepatic cholestasis (eg, sure medication, biliary cirrhosis, sepsis, postoperative jaundice) Hepatocellular injury or intrahepatic cholestasis resulting from miscellaneous causes (eg, spirochetal infections, infectious mononucleosis, cholangitis, sarcoidosis, lymphomas, industrial toxins) Biliary Obstruction Choledocholithiasis, biliary atresia, carcinoma of biliary duct, sclerosing cholangitis, choledochal cyst, external pressure on bile duct, pancreatitis, pancreatic neoplasms Table sixteen-2. 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