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Clinical features of 21-hydroxylase deficiencyAcute adrenal insufficiency Due to lack of cortisol and aldosterone High blood stress Salt-craving Dehydration Vomiting Genital ambiguity Due to excess androgens Affects females solely Known as ‘feminine pseudohermaphroditism’ Enlarged clitoris Partial or full fusion of labia External genitalia might resemble a penis Late-onset in females Virilisation: deepened voice, small breasts, increased muscle bulk, enlarged clitoris, elevated libido Absent or irregular menstrual periods Male pattern of hair development (hirsutism) Oily pores and skin (seborrhoea) Acne Androgenetic alopecia Late-onset in males Premature puberty Accelerated bone age Enlargement of testes, due to adrenal tissue growing within the testes How is the prognosis made. 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