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Time of Optimal Suboptimal Failure Warnings Evaluation, Response Response Months Baseline Not relevant Not applicable Not relevant High Sokal rating, other clonal chromosome abnormalities in Ph+ cells* 3 Complete hematologic No cytogenetic response Less than complete Not applicable response or no less than (Ph+ > ninety five%) hematologic response minor cytogenetic response (Ph+ ≤ sixty five%) 6 At least partial cyto- Less than partial No cytogenetic Not applicable genetic response cytogenetic response response (Ph+ > 95%) (Ph+ ≤ 35%) (Ph+ > 35%) 12 Complete cytogenetic Partial cytogenetic Less than partial Less than major response response (Ph+ 1-35%) cytogenetic response molecular response** (Ph+ > % 35) 18 Major molecular Less than main Less than full Not applicable response** molecular response** cytogenetic response Any time throughout Stable or enhancing Loss of major molecular Loss of complete Increase in transcript degree***** therapy major molecular response**, mutations*** hematologic response* other clonal chromosome response or complete cytogenetic abnormalities in Ph– cells response, mutations****, other clonal chromosome abnormalities in Ph+ cells * the identical clonal chromosome abnormality in a minimum of two Ph+ cells have to be shown in two consecutive cytogenetic exams. 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