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Grade for the Overall Quality of Evidence Grade Quality Level Definition A High We are confident that the true results lies near that of the estimates of the effect B Moderate The true effects are likely to be near the estimates of the results, but there is a possibility that they are substantially different C Low The true results might be substantially totally different from the estimates of effects D Very low The estimates are very uncertain, and often might be removed from the truth. The pieces of apparatus on the Luxembourg list have been examined against the affordability and value-effectiveness benchmarks, with the requirement of assembly the affordability benchmark (as a dominant criterion) and the fee-intensiveness benchmark to be able to be cost-intensive diabetes doctor buy 500 mg actoplus met amex. 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